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Issue 52, 2016, Issue in Progress
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Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

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Abstract

The natural tripeptide glutathione has become a popular choice for passivating the surface of gold nanoparticles (NPs) intended for in vivo applications. Here we investigate a zwitterionic derivative of glutathione – glutathione monoethyl ester – as a new capping ligand for ultrasmall NPs. The new zwitterionic particles (AuGSH(zwt)) were colloidally stable in biological media and resistant against binding from serum proteins. AuGSH(zwt), but not glutathione-coated particles, could be successfully functionalized with strep-tag II for binding specifically to target streptactin in the presence of serum proteins. Taken together, these results place AuGSH(zwt) as a promising choice for attaining simultaneous in vivo renal clearance and targeted delivery via incorporation of functional peptides.

Graphical abstract: Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

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Publication details

The article was received on 25 Mar 2016, accepted on 04 May 2016 and first published on 06 May 2016


Article type: Communication
DOI: 10.1039/C6RA07777C
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2016,6, 46350-46355
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    Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

    L. L. Knittel, P. Schuck, C. J. Ackerson and A. A. Sousa, RSC Adv., 2016, 6, 46350
    DOI: 10.1039/C6RA07777C

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