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Issue 40, 2016, Issue in Progress
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Nanogold POxylation: towards always-on fluorescent lung cancer targeting

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Abstract

Gold nanoparticles (GNPs) are one of most investigated nanomaterials for lung cancer diagnosis and therapy (theragnosis). For imaging purposes, GNPs are often tagged with fluorescent probes, but unfortunately the associated plasmon resonance effect leads to fluorescence self-quenching, thus precluding accurate localization. In this study, biocompatible GNPs targeted with a laminin fragment were successfully engineered using fluorescent oligo-oxazolines produced in supercritical carbon dioxide. The architecture and properties of the POxylated constructs were fully characterized and confocal laser scanning microscopy measurements demonstrated a higher cellular uptake into A549 lung cancer cells through an active targeting mechanism.

Graphical abstract: Nanogold POxylation: towards always-on fluorescent lung cancer targeting

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Publication details

The article was received on 07 Jan 2016, accepted on 28 Mar 2016 and first published on 29 Mar 2016


Article type: Communication
DOI: 10.1039/C6RA00532B
Citation: RSC Adv., 2016,6, 33631-33635
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    Nanogold POxylation: towards always-on fluorescent lung cancer targeting

    A. S. Silva, M. C. Silva, S. P. Miguel, V. D. B. Bonifácio, I. J. Correia and A. Aguiar-Ricardo, RSC Adv., 2016, 6, 33631
    DOI: 10.1039/C6RA00532B

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