Synthesis of [123I]-iodometomidate from a polymer-supported precursor with a large excluded volume

Chika Nakagawa; Masahito Toyama; Ryota Takeuchi; Takashi Takahashi; Hiroshi Tanaka

doi:10.1039/C6RA00442C

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Synthesis of [¹²³I]-iodometomidate from a polymer-supported precursor with a large excluded volume†

Chika Nakagawa,^a Masahito Toyama,^b Ryota Takeuchi,^a Takashi Takahashi ‡^a and Hiroshi Tanaka*^a

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* Corresponding authors

^a Department of Applied Chemistry, Graduate School of Science and Engineering Tokyo Institute of Technology, 2-12-1-H-101 Ookayama, Meguro, Tokyo 152-8552, Japan
E-mail: thiroshi@apc.titech.ac.jp

^b Nihon Medi-Physics, 3-1, Kitasode, Sodegaura-Shi, Chiba 299-0266, Japan

Abstract

We report on the synthesis of [¹²³I]-iodometomidate from a soluble polymer-supported precursor. The precursor was linked through a soluble polymer via a silyl linker polymer-supported precursor and released [¹²³I]-iodometomidate. The radiotracers were purified based on a combination of size-exclusive and normal-phase chromatography to provide [¹²³I]-iodometomidate in good quality.

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Article information

DOI: https://doi.org/10.1039/C6RA00442C
Article type: Communication
Submitted: 07 Jan 2016
Accepted: 15 Jan 2016
First published: 19 Jan 2016

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RSC Adv., 2016,6, 12215-12218

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Synthesis of [¹²³I]-iodometomidate from a polymer-supported precursor with a large excluded volume

C. Nakagawa, M. Toyama, R. Takeuchi, T. Takahashi and H. Tanaka, RSC Adv., 2016, 6, 12215 DOI: 10.1039/C6RA00442C

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