Issue 31, 2016
From the journal:

RSC Advances

Pharmaceutical crystalline complexes of sulfamethazine with saccharin: same interaction site but different ionization states†

Xue Fu,ab   Jianhui Li,b   Lianyan Wang,b   Bing Wu,c   Xu Xu,*a   Zongwu Dengb  and  Hailu Zhang*b  

* Corresponding authors

a School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201408, P. R. China
E-mail: xuxu@sit.edu.cn
Tel: +86-21-60873372

b Laboratory of Magnetic Resonance Spectroscopy and Imaging, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, P. R. China
E-mail: hlzhang2008@sinano.ac.cn
Fax: +86-512-62603079
Tel: +86-512-62872713

c Analysis and Testing Center, Soochow University, Suzhou 215123, P. R. China

Abstract

Sulfamethazine (SMT), a widely used antibacterial drug, can form either a 1 : 1 salt or a 1 : 1 cocrystal with saccharin (SAC), an artificial sweetener. Interestingly, the two crystalline complexes possess the same main intermolecular interaction sites, except the locations of the acidic proton are different.

Graphical abstract: Pharmaceutical crystalline complexes of sulfamethazine with saccharin: same interaction site but different ionization states

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Article information

DOI
https://doi.org/10.1039/C5RA27759K
Article type
Communication
Submitted
26 Dec 2015
Accepted
03 Mar 2016
First published
04 Mar 2016

RSC Adv., 2016,6, 26474-26478

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Pharmaceutical crystalline complexes of sulfamethazine with saccharin: same interaction site but different ionization states

X. Fu, J. Li, L. Wang, B. Wu, X. Xu, Z. Deng and H. Zhang, RSC Adv., 2016, 6, 26474 DOI: 10.1039/C5RA27759K

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