Discovery of a novel human lactate dehydrogenase A (LDHA) inhibitor as an anti-proliferation agent against MIA PaCa-2 pancreatic cancer cells

Abstract

LDHA has recently emerged as an attractive target for cancer therapy. Herein, we present the discovery of a potent LDHA inhibitor 12, which has good inhibitory activity to LDHA (IC₅₀ = 1.50 μM). Moreover, the inhibitor 12 strongly inhibits the proliferation of MIA PaCa-2 pancreatic cancer cells (EC₅₀ = 3.16 μM), suggesting it could serve as a promising candidate for further investigation.