Issue 11, 2016
From the journal:

RSC Advances

A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy†

Jingguo Li,ab   Lu Zhang,a   Yujie Lin,a   Hong Xiao,a   Mingxiang Zuo,a   Du Chenga  and  Xintao Shuai*a  

* Corresponding authors

a PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
E-mail: shuaixt@mail.sysu.edu.cn
Fax: +86-20-84112245
Tel: +86-20-84110365

b People's Hospital of Zhengzhou University, Zhengzhou, China

Abstract

A novel tetra-doxorubicin-tailed polyethylene glycol via benzoic-imine bond linkage was synthesized and self-assembled to a pH-sensitive prodrug micelle. This micelle not only effectively entered cancer cells but also quickly released doxorubicin (DOX) in tumor sites to exert anticancer activity in vitro.

Graphical abstract: A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy

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Article information

DOI
https://doi.org/10.1039/C5RA27293A
Article type
Communication
Submitted
21 Dec 2015
Accepted
10 Jan 2016
First published
14 Jan 2016

RSC Adv., 2016,6, 9160-9163

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A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy

J. Li, L. Zhang, Y. Lin, H. Xiao, M. Zuo, D. Cheng and X. Shuai, RSC Adv., 2016, 6, 9160 DOI: 10.1039/C5RA27293A

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