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Issue 1, 2017
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Controlling chemoselectivity in copper-catalyzed decarboxylative A3/A3 cross-couplings: direct formation of unsymmetrical 1,4-diamino-2-butynes

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Abstract

A direct cross-coupling of propiolic acid with two kinds of in situ formed iminiums has been achieved via the CuI/CuCl2-catalyzed decarboxylative A3/A3 domino process. This novel protocol to synthesise unsymmetrical 1,4-diamino-2-butynes is operationally simple in an atom- and step-economical manner, and provides products in moderate to excellent yields with high chemoselectivity.

Graphical abstract: Controlling chemoselectivity in copper-catalyzed decarboxylative A3/A3 cross-couplings: direct formation of unsymmetrical 1,4-diamino-2-butynes

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Publication details

The article was received on 29 Aug 2016, accepted on 09 Oct 2016, published on 10 Oct 2016 and first published online on 10 Oct 2016


Article type: Research Article
DOI: 10.1039/C6QO00499G
Citation: Org. Chem. Front., 2017,4, 37-41
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    Controlling chemoselectivity in copper-catalyzed decarboxylative A3/A3 cross-couplings: direct formation of unsymmetrical 1,4-diamino-2-butynes

    P. Zhao, H. Feng, H. Pan, Z. Sun and M. Tong, Org. Chem. Front., 2017, 4, 37
    DOI: 10.1039/C6QO00499G

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