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Issue 12, 2016
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Synthesis of spiro[indane-1,3-dione-1-pyrrolines] via copper-catalyzed heteroannulation of ketoxime acetates with 2-arylideneindane-1,3-diones

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Abstract

A cuprous cyanide-catalyzed heteroannulation reaction of 2-arylideneindane-1,3-dione with ketoxime acetates has been developed for the synthesis of novel spiro[indane-1,3-dione-1-pyrrolines] through the cleavage of N–O and C–H bonds and formation of C–C and C–N bonds. The synthetic strategy shows broad substrate scope and furnishes spiro[indane-1,3-dione-1-pyrrolines] in high yields.

Graphical abstract: Synthesis of spiro[indane-1,3-dione-1-pyrrolines] via copper-catalyzed heteroannulation of ketoxime acetates with 2-arylideneindane-1,3-diones

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Publication details

The article was received on 12 Aug 2016, accepted on 26 Sep 2016 and first published on 27 Sep 2016


Article type: Research Article
DOI: 10.1039/C6QO00454G
Citation: Org. Chem. Front., 2016,3, 1614-1618
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    Synthesis of spiro[indane-1,3-dione-1-pyrrolines] via copper-catalyzed heteroannulation of ketoxime acetates with 2-arylideneindane-1,3-diones

    J. Duan, Y. Cheng, R. Li and P. Li, Org. Chem. Front., 2016, 3, 1614
    DOI: 10.1039/C6QO00454G

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