Jump to main content
Jump to site search

Issue 11, 2016
Previous Article Next Article

Manganese-catalyzed ring-opening chlorination of cyclobutanols: regiospecific synthesis of γ-chloroketones

Author affiliations

Abstract

We disclose an efficient manganese-catalyzed ring-opening chlorination of cyclobutanols. This reaction has a broad substrate scope, affording a variety of γ-chloro alkyl ketones and medium-sized benzocyclic chlorides in synthetically useful yields and unique regioselectivities. The merits including mild reaction conditions and employment of inexpensive catalysts and reagents make it a practical approach for the production of γ-chlorinated ketones.

Graphical abstract: Manganese-catalyzed ring-opening chlorination of cyclobutanols: regiospecific synthesis of γ-chloroketones

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Aug 2016, accepted on 03 Sep 2016 and first published on 05 Sep 2016


Article type: Research Article
DOI: 10.1039/C6QO00443A
Citation: Org. Chem. Front., 2016,3, 1467-1471
  •   Request permissions

    Manganese-catalyzed ring-opening chlorination of cyclobutanols: regiospecific synthesis of γ-chloroketones

    L. Huan and C. Zhu, Org. Chem. Front., 2016, 3, 1467
    DOI: 10.1039/C6QO00443A

Search articles by author

Spotlight

Advertisements