Issue 1, 2017

Metal-free molecular iodine-catalyzed direct sulfonylation of pyrazolones with sodium sulfinates leading to sulfonated pyrazoles at room temperature

Abstract

A simple and convenient molecular iodine-catalyzed direct sulfonylation of pyrazolones with sodium sulfinates has been developed in the presence of TBHP at room temperature. This methodology can allow for the synthesis of a series of valuable sulfonated pyrazoles in good to excellent yields simply using readily-available starting materials without requiring any metal or cryogenics.

Graphical abstract: Metal-free molecular iodine-catalyzed direct sulfonylation of pyrazolones with sodium sulfinates leading to sulfonated pyrazoles at room temperature

Supplementary files

Article information

Article type
Research Article
Submitted
01 Sep 2016
Accepted
07 Oct 2016
First published
08 Oct 2016

Org. Chem. Front., 2017,4, 26-30

Metal-free molecular iodine-catalyzed direct sulfonylation of pyrazolones with sodium sulfinates leading to sulfonated pyrazoles at room temperature

W. Wei, H. Cui, D. Yang, X. Liu, C. He, S. Dai and H. Wang, Org. Chem. Front., 2017, 4, 26 DOI: 10.1039/C6QO00403B

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