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Issue 11, 2016
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Multigram chromatography-free synthesis of octa(ethylene glycol) p-toluenesulfonate

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Abstract

Here we report a detailed synthetic procedure for monodisperse octa(ethylene glycol) p-toluenesulfonate, a member of the heterobifunctional oligo(ethylene glycol) derivatives family. The method offers completely chromatography-free workup and purification, resulting in higher yields and a lower cost than any of the alternative strategies. We also introduce several upgrades, simplifying the method even more, and discuss the chromatography-free design limitations.

Graphical abstract: Multigram chromatography-free synthesis of octa(ethylene glycol) p-toluenesulfonate

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Publication details

The article was received on 27 Jul 2016, accepted on 03 Sep 2016 and first published on 06 Sep 2016


Article type: Method
DOI: 10.1039/C6QO00398B
Citation: Org. Chem. Front., 2016,3, 1524-1534
  • Open access: Creative Commons BY-NC license
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    Multigram chromatography-free synthesis of octa(ethylene glycol) p-toluenesulfonate

    A. M. Wawro, T. Muraoka, M. Kato and K. Kinbara, Org. Chem. Front., 2016, 3, 1524
    DOI: 10.1039/C6QO00398B

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