Jump to main content
Jump to site search

Issue 11, 2016
Previous Article Next Article

Multigram chromatography-free synthesis of octa(ethylene glycol) p-toluenesulfonate

Author affiliations

Abstract

Here we report a detailed synthetic procedure for monodisperse octa(ethylene glycol) p-toluenesulfonate, a member of the heterobifunctional oligo(ethylene glycol) derivatives family. The method offers completely chromatography-free workup and purification, resulting in higher yields and a lower cost than any of the alternative strategies. We also introduce several upgrades, simplifying the method even more, and discuss the chromatography-free design limitations.

Graphical abstract: Multigram chromatography-free synthesis of octa(ethylene glycol) p-toluenesulfonate

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Jul 2016, accepted on 03 Sep 2016 and first published on 06 Sep 2016


Article type: Method
DOI: 10.1039/C6QO00398B
Citation: Org. Chem. Front., 2016,3, 1524-1534
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Multigram chromatography-free synthesis of octa(ethylene glycol) p-toluenesulfonate

    A. M. Wawro, T. Muraoka, M. Kato and K. Kinbara, Org. Chem. Front., 2016, 3, 1524
    DOI: 10.1039/C6QO00398B

Search articles by author

Spotlight

Advertisements