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Issue 11, 2016
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Visible-light-induced three-component 1,2-difluoroalkylarylation of styrenes with α-carbonyl difluoroalkyl bromides and indoles

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Abstract

A novel visible light photoredox catalysis three-component 1,2-difluoroalkylarylation of styrenes was disclosed, and two new C–C bonds were generated in a single step through regioselective incorporation of a CF2 group and a variety of indoles to C[double bond, length as m-dash]C bonds. The well-designed photoredox system achieved the synthesis of a series of difluoro-containing indole derivatives with mild conditions and a broad substrate scope.

Graphical abstract: Visible-light-induced three-component 1,2-difluoroalkylarylation of styrenes with α-carbonyl difluoroalkyl bromides and indoles

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Publication details

The article was received on 26 Jul 2016, accepted on 29 Aug 2016 and first published on 30 Aug 2016


Article type: Research Article
DOI: 10.1039/C6QO00393A
Citation: Org. Chem. Front., 2016,3, 1443-1446
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    Visible-light-induced three-component 1,2-difluoroalkylarylation of styrenes with α-carbonyl difluoroalkyl bromides and indoles

    Y. Duan, W. Li, P. Xu, M. Zhang, Y. Cheng and C. Zhu, Org. Chem. Front., 2016, 3, 1443
    DOI: 10.1039/C6QO00393A

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