Issue 10, 2016
From the journal:

Organic Chemistry Frontiers

Cp*Co(iii)-catalyzed, N–N bond-based redox-neutral synthesis of isoquinolines†

Jie Wang,a   Shanke Zha,a   Kehao Chena  and  Jin Zhu*a  

* Corresponding authors

a Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, China
E-mail: jinz@nju.edu.cn

Abstract

We report herein a redox-neutral Cp*Co(III)-catalyzed cyclization of acetophenone N-Boc hydrazones with alkynes for streamlined synthesis of isoquinolines, accomplished via formation of a C–C and a C–N bond along with N–N bond cleavage. Moreover, this rapid approach can be completed in 30 min with yields up to 85%.

Graphical abstract: Cp*Co(iii)-catalyzed, N–N bond-based redox-neutral synthesis of isoquinolines

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Article information

DOI
https://doi.org/10.1039/C6QO00367B
Article type
Research Article
Submitted
18 Jul 2016
Accepted
07 Aug 2016
First published
08 Aug 2016

Org. Chem. Front., 2016,3, 1281-1285

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Cp*Co(III)-catalyzed, N–N bond-based redox-neutral synthesis of isoquinolines

J. Wang, S. Zha, K. Chen and J. Zhu, Org. Chem. Front., 2016, 3, 1281 DOI: 10.1039/C6QO00367B

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