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Issue 11, 2016
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LDA-mediated synthesis of ortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature

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Abstract

An efficient and facile method for the synthesis of ortho-cyanated diarylmethane by reaction of fluoroarene with arylacetonitrile in the presence of LDA (lithium diisopropylamide) at room temperature was developed. The reaction of arylacetonitrile with electron-rich fluoroarene involves the formation of an aryne intermediate.

Graphical abstract: LDA-mediated synthesis of ortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature

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Publication details

The article was received on 18 Jul 2016, accepted on 22 Aug 2016 and first published on 26 Aug 2016


Article type: Research Article
DOI: 10.1039/C6QO00363J
Citation: Org. Chem. Front., 2016,3, 1425-1429
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    LDA-mediated synthesis of ortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature

    F. Liang, X. Ji, J. Zhang and S. Cao, Org. Chem. Front., 2016, 3, 1425
    DOI: 10.1039/C6QO00363J

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