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Issue 11, 2016
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Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents

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Abstract

Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines 3a–c as potential anticancer agents was achieved by employing stereoselective cyclopropanation, stereoselective nucleophilic addition, regioselective isopropylidene cleavage and regioselective base condensation of cyclic sulfate as key steps.

Graphical abstract: Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents

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Publication details

The article was received on 14 Jul 2016, accepted on 03 Sep 2016 and first published on 05 Sep 2016


Article type: Research Article
DOI: 10.1039/C6QO00358C
Citation: Org. Chem. Front., 2016,3, 1472-1480
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    Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents

    S. D. Naik, G. Chandra, P. K. Sahu, H. Kim, S. Qu, J. Yoon and L. S. Jeong, Org. Chem. Front., 2016, 3, 1472
    DOI: 10.1039/C6QO00358C

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