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Issue 11, 2016
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A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry

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Abstract

The present work describes the unprecedented use of Fluoroalkyl Amino Reagents (FARs) to afford 2,4-bis(fluoroalkyl)-substituted quinoline derivatives in two steps. In contrast to the Combes reaction, this approach allows for the synthesis of numerous quinoline derivatives bearing two identical or different fluoroalkyl substituents in the 2 and 4 positions, under mild reaction conditions, in good yields and with a very good regioselectivity. This reaction is easily scalable and suitable for an industrial process.

Graphical abstract: A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry

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Publication details

The article was received on 30 Jun 2016, accepted on 27 Jul 2016 and first published on 29 Jul 2016


Article type: Research Article
DOI: 10.1039/C6QO00319B
Citation: Org. Chem. Front., 2016,3, 1392-1415
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    A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry

    F. Aribi, E. Schmitt, A. Panossian, J. Vors, S. Pazenok and F. R. Leroux, Org. Chem. Front., 2016, 3, 1392
    DOI: 10.1039/C6QO00319B

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