Jump to main content
Jump to site search

Issue 11, 2016
Previous Article Next Article

Iodine-promoted sequential dual oxidative Csp3–H amination/Csp3–H iodination reactions: efficient synthesis of 1-iodoimidazo[1,5-a]pyridines

Author affiliations

Abstract

An iodine-promoted sequential dual oxidative Csp3–H amination of aryl methyl ketones and Csp3–H iodination of pyridin-2-ylmethylamines have been realized for the first time. This simple and efficient approach constructed 1-iodoimidazo[1,5-a]pyridines in moderate to good yields. Based on the preliminary experimental results, a self-sequenced process featuring the iodination/Kornblum oxidation/dual amination/oxidation/iodination mechanism was proposed.

Graphical abstract: Iodine-promoted sequential dual oxidative Csp3–H amination/Csp3–H iodination reactions: efficient synthesis of 1-iodoimidazo[1,5-a]pyridines

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 29 Jun 2016, accepted on 29 Aug 2016 and first published on 30 Aug 2016


Article type: Research Article
DOI: 10.1039/C6QO00313C
Citation: Org. Chem. Front., 2016,3, 1430-1434
  •   Request permissions

    Iodine-promoted sequential dual oxidative Csp3–H amination/Csp3–H iodination reactions: efficient synthesis of 1-iodoimidazo[1,5-a]pyridines

    Y. Wu, X. Geng, Q. Gao, J. Zhang, X. Wu and A. Wu, Org. Chem. Front., 2016, 3, 1430
    DOI: 10.1039/C6QO00313C

Search articles by author