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Issue 11, 2016
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A new method to access triazole-fused spiro-guanidines from the reaction of isothiocyanates tethered N-sulfonyl-1,2,3-triazoles and amines

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Abstract

A novel method to access triazole-fused spiro-guanidine from the reaction of isothiocyanate tethered N-sulfonyl-1,2,3-triazoles and amine has been developed. The reactions proceeded through a two-component tandem reaction, including nucleophilic addition, base-assisted intramolecular (or intermolecular) nucleophilic substitution and subsequent intramolecular nucleophilic addition–elimination process. A wide range of protected oxindole skeletons and amines are well-tolerated.

Graphical abstract: A new method to access triazole-fused spiro-guanidines from the reaction of isothiocyanates tethered N-sulfonyl-1,2,3-triazoles and amines

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Publication details

The article was received on 28 Jun 2016, accepted on 20 Aug 2016 and first published on 22 Aug 2016


Article type: Research Article
DOI: 10.1039/C6QO00304D
Citation: Org. Chem. Front., 2016,3, 1447-1451
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    A new method to access triazole-fused spiro-guanidines from the reaction of isothiocyanates tethered N-sulfonyl-1,2,3-triazoles and amines

    H. Liu, Y. Jiang, J. Hao, X. Tang and M. Shi, Org. Chem. Front., 2016, 3, 1447
    DOI: 10.1039/C6QO00304D

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