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Issue 11, 2016
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Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations

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Abstract

While in the early days of palladium-catalyzed allylic alkylations mainly stabilized carbanions, such as malonates, have been used as standard nucleophiles, during the last 10–15 years also non stabilized enolates became more and more popular. Efficient protocols have been developed allowing their highly regio- as well as stereoselective allylations. In addition, catalysts based on other transition metals enlarge the synthetic potential of these valuable transformations, since each metal (complex) shows its own, typical reaction behaviour. This review will cover the new developments in this fast developing field.

Graphical abstract: Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations

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Publication details

The article was received on 09 May 2016, accepted on 16 Aug 2016 and first published on 23 Aug 2016


Article type: Review Article
DOI: 10.1039/C6QO00192K
Citation: Org. Chem. Front., 2016,3, 1541-1560
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    Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations

    U. Kazmaier, Org. Chem. Front., 2016, 3, 1541
    DOI: 10.1039/C6QO00192K

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