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Issue 7, 2016
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On the fly multi-modal observation of ligand synthesis and complexation of Cu complexes in flow with ‘benchtop’ NMR and mass spectrometry

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Abstract

Exploring complex chemical systems requires reproducible and controllable ways to access non-equilibrium conditions. Herein we present a programmable flow system that can do both ligand synthesis and complexation on the fly, and the conditions of the reaction can be monitored using two simultaneous techniques, namely NMR and mass spectrometry. By using this approach we monitored the formation of unknown complexes, followed by crystallization that resulted in the characterisation of their structures giving 5 new compounds (4 isolated and fully characterised) which can be formulated as: Cu2(L1)4(μ-CO3)](BF4)2 (2); [Cu3(L1)6(μ-CO3)](PF6)2(OH)2 (3) [Cu2(L2)2](BF4)2 (4) and [Cu(L2)2](BF4)2·CH3CN (5).

Graphical abstract: On the fly multi-modal observation of ligand synthesis and complexation of Cu complexes in flow with ‘benchtop’ NMR and mass spectrometry

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Publication details

The article was received on 05 Apr 2016, accepted on 11 May 2016 and first published on 11 May 2016


Article type: Research Article
DOI: 10.1039/C6QI00079G
Citation: Inorg. Chem. Front., 2016,3, 919-923
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    On the fly multi-modal observation of ligand synthesis and complexation of Cu complexes in flow with ‘benchtop’ NMR and mass spectrometry

    L. Porwol, A. Henson, P. J. Kitson, D. Long and L. Cronin, Inorg. Chem. Front., 2016, 3, 919
    DOI: 10.1039/C6QI00079G

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