Issue 42, 2016

Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

Abstract

Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.

Graphical abstract: Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

Supplementary files

Article information

Article type
Paper
Submitted
19 Sep 2016
Accepted
05 Oct 2016
First published
05 Oct 2016

Polym. Chem., 2016,7, 6529-6544

Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

A. Cappelli, M. Paolino, G. Grisci, V. Razzano, G. Giuliani, A. Donati, C. Bonechi, R. Mendichi, S. Battiato, F. Samperi, C. Scialabba, G. Giammona, F. Makovec and M. Licciardi, Polym. Chem., 2016, 7, 6529 DOI: 10.1039/C6PY01644H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements