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Issue 42, 2016
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Acid and base dual-controlled cargo molecule release from polyaniline gated-hollow mesoporous silica nanoparticles

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Abstract

Polyaniline (PANI) chains with different lengths were grafted onto the surface of hollow mesoporous silica spheres (HMSs) by in situ chemical oxidative polymerization. In the cargo-loading experiments, HMSs-PANI(L) with long PANI chains was unsuitable to load Doxorubicin (DOX) hydrochloride molecules because of channel blockage. In contrast, the oligomer of PANI chains served as the gate, and when grafted onto HMSs (HMSs-PANI(S)), they simply manipulated the “opening” or “closing” of mesopores through the doping mechanism of PANI chains. Utilizing the different states of PANI chains led to the different interaction forces between PANI chains and cargo molecules, and HMSs-PANI(S) can effectively load different cargo molecules. When stimulated by using an acid, the acid-controlled release behaviors of DOX and Rhodamine 6G (R6G) were achieved. When stimulated by using an acid, alkaline controlled release behavior was also observed by loading indomethacin (IND) molecules.

Graphical abstract: Acid and base dual-controlled cargo molecule release from polyaniline gated-hollow mesoporous silica nanoparticles

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Publication details

The article was received on 28 Aug 2016, accepted on 26 Sep 2016 and first published on 27 Sep 2016


Article type: Paper
DOI: 10.1039/C6PY01507G
Citation: Polym. Chem., 2016,7, 6467-6474
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    Acid and base dual-controlled cargo molecule release from polyaniline gated-hollow mesoporous silica nanoparticles

    X. Zhu, J. Zhao and C. Wang, Polym. Chem., 2016, 7, 6467
    DOI: 10.1039/C6PY01507G

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