Jump to main content
Jump to site search

Issue 2, 2016
Previous Article Next Article

Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

Author affiliations

Abstract

Thermoresponsive polymers are used to produce nanoparticles or nanoaggregates for a wide range of applications such as nanomedicine. However, low-toxicity, thermoresponsive polymers such as methacrylate polymers with short oligo(ethylene glycol) side chains are not readily applicable to the synthesis of nanoaggregates with both spherical and nonspherical morphologies. Here we report the synthesis of a low-toxicity, thermoresponsive copolymer, P(DEGMA-co-HPMA), and describe its application in the RAFT-mediated emulsion polymerization of styrene as a means to produce nanoparticles with tuneable morphology (sphere, cylinder, vesicle and lamella). These nanoaggregates offer considerable potential as a novel platform for the next generation of nanotherapeutics with improved efficacy.

Graphical abstract: Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 11 Sep 2015, accepted on 08 Nov 2015 and first published on 16 Nov 2015


Article type: Paper
DOI: 10.1039/C5PY01467K
Citation: Polym. Chem., 2016,7, 430-440
  •   Request permissions

    Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

    N. P. Truong, M. R. Whittaker, A. Anastasaki, D. M. Haddleton, J. F. Quinn and T. P. Davis, Polym. Chem., 2016, 7, 430
    DOI: 10.1039/C5PY01467K

Search articles by author