Jump to main content
Jump to site search

Issue 4, 2016
Previous Article Next Article

Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

Author affiliations

Abstract

We introduce a novel double-hydrophilic hydroxyethylmethacrylate (HEMA) based diblock glycopolymer which self-assembles into homogeneous spherical micellar structures in water. The micellar structure renders surface-oriented N-acetylglucocosamine (GlcNAc) sugar moieties for strong multivalent glycan-mediated lectin binding. Structural analysis and lectin binding is performed by microscopy methods, dynamic light scattering (DLS) and two-focus fluorescence correlation spectroscopy (2fFCS), revealing a novel micellar type of multivalent sugar binding scaffold with high potential for biomedical applications.

Graphical abstract: Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 May 2015, accepted on 30 Nov 2015 and first published on 02 Dec 2015


Article type: Paper
DOI: 10.1039/C5PY00797F
Citation: Polym. Chem., 2016,7, 878-886
  •   Request permissions

    Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

    H. Park, S. Walta, R. R. Rosencrantz, A. Körner, C. Schulte, L. Elling, W. Richtering and A. Böker, Polym. Chem., 2016, 7, 878
    DOI: 10.1039/C5PY00797F

Search articles by author

Spotlight

Advertisements