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Issue 47, 2016
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A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical cyclization: synthesis of a cyclic RGD peptide

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Abstract

A cyclic RGD peptide was efficiently synthesized based on micro-flow, triphosgene-mediated peptide chain elongation and micro-flow photochemical macrolactamization. Our approach enabled a rapid (amidation for peptide chain elongation <5 s, macrolactamization <5 min) and clean (only one column chromatographic separation) synthesis of a cyclic peptide.

Graphical abstract: A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical cyclization: synthesis of a cyclic RGD peptide

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Publication details

The article was received on 03 Nov 2016, accepted on 09 Nov 2016 and first published on 16 Nov 2016


Article type: Paper
DOI: 10.1039/C6OB02391F
Citation: Org. Biomol. Chem., 2016,14, 11244-11249
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    A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical cyclization: synthesis of a cyclic RGD peptide

    Y. Mifune, H. Nakamura and S. Fuse, Org. Biomol. Chem., 2016, 14, 11244
    DOI: 10.1039/C6OB02391F

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