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Issue 46, 2016
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Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method

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Abstract

A single-step continuous flow method has been developed that gives expedited access to complex heterocycles via an intramolecular photochemical cyclization. Herein we report the first examples of the photochemically-induced generation of thieno[3,2-c]quinolin-4(5H)-ones, 16 examples, and benzo[h]-1,6-naphthyridin-5(6H)-ones, 6 examples. Overall, the continuous flow method provides access to complex heterocycles in two steps from commercially available starting materials in good yields and with greater atom efficiency than traditional batch reactions.

Graphical abstract: Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method

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Publication details

The article was received on 18 Oct 2016, accepted on 03 Nov 2016 and first published on 03 Nov 2016


Article type: Communication
DOI: 10.1039/C6OB02279K
Citation: Org. Biomol. Chem., 2016,14, 10799-10803
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    Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method

    Y. Fang and G. K. Tranmer, Org. Biomol. Chem., 2016, 14, 10799
    DOI: 10.1039/C6OB02279K

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