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Issue 45, 2016
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Synthesis of quinazolines from 2-aminobenzylamines with benzylamines and N-substituted benzylamines under transition metal-free conditions

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Abstract

This work reports the synthesis of quinazolines from 2-aminobenzylamines with N-substituted benzylamines in the presence of molecular iodine. The developed methodology works smoothly under transition-metal free, additive free and solvent free conditions. The use of O2 as a green oxidant makes it a greatly economical, green and sustainable protocol. Moreover, no aqueous work up is required thereby enhancing the efficiency. A series of quinazoline derivatives were synthesized successfully in good to excellent yields.

Graphical abstract: Synthesis of quinazolines from 2-aminobenzylamines with benzylamines and N-substituted benzylamines under transition metal-free conditions

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Publication details

The article was received on 04 Oct 2016, accepted on 18 Oct 2016 and first published on 18 Oct 2016


Article type: Communication
DOI: 10.1039/C6OB02163H
Citation: Org. Biomol. Chem., 2016,14, 10567-10571
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    Synthesis of quinazolines from 2-aminobenzylamines with benzylamines and N-substituted benzylamines under transition metal-free conditions

    A. R. Tiwari and B. M. Bhanage, Org. Biomol. Chem., 2016, 14, 10567
    DOI: 10.1039/C6OB02163H

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