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Issue 43, 2016
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BF3·Et2O mediated one-step synthesis of N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines

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Abstract

A simple and efficient one-pot synthesis of N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines by a BF3·Et2O mediated novel methodology, from easily available α,β-unsaturated ketones/arylidene ketones, phenyl acetylenes and substituted nitriles, has been described. This novel annulation provides quick access to complex polycyclic frameworks with an excellent substrate scope.

Graphical abstract: BF3·Et2O mediated one-step synthesis of N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines

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Publication details

The article was received on 30 Sep 2016, accepted on 06 Oct 2016 and first published on 06 Oct 2016


Article type: Communication
DOI: 10.1039/C6OB02133F
Citation: Org. Biomol. Chem., 2016,14, 10165-10169
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    BF3·Et2O mediated one-step synthesis of N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines

    C. T. Fathimath Salfeena, K. T. Ashitha and B. S. Sasidhar, Org. Biomol. Chem., 2016, 14, 10165
    DOI: 10.1039/C6OB02133F

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