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Issue 43, 2016
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Transition-metal-free oxidative C5 C–H-halogenation of 8-aminoquinoline amides using sodium halides

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Abstract

A simple and efficient transition-metal-free oxidative halogenation (Cl, Br) of the C5 C–H bond of 8-aminoquinoline amides has been developed. This method employed low-cost and innoxious sodium halides as halogenation reagents and oxone as an oxidant. The reactions demonstrated air and moisture tolerance, and good functional group compatibility, giving highly selective C5-halogenated products in good to excellent yields.

Graphical abstract: Transition-metal-free oxidative C5 C–H-halogenation of 8-aminoquinoline amides using sodium halides

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Publication details

The article was received on 22 Sep 2016, accepted on 13 Oct 2016 and first published on 13 Oct 2016


Article type: Communication
DOI: 10.1039/C6OB02079H
Citation: Org. Biomol. Chem., 2016,14, 10180-10184
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    Transition-metal-free oxidative C5 C–H-halogenation of 8-aminoquinoline amides using sodium halides

    Y. Wang, Y. Wang, K. Jiang, Q. Zhang and D. Li, Org. Biomol. Chem., 2016, 14, 10180
    DOI: 10.1039/C6OB02079H

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