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Issue 42, 2016
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Enolate-mediated 1,3-dipolar cycloaddition reactions of allyl ketones with nitrile oxides: direct access to 3,5-disubstituted isoxazolines

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Abstract

TMG-promoted [3 + 2] organocatalytic 1,3-dipolar cycloaddition reactions of allyl ketones with in situ generated nitrile oxides have been developed. This strategy could generate 3,5-disubstituted isoxazolines in high yields and regioselectivities.

Graphical abstract: Enolate-mediated 1,3-dipolar cycloaddition reactions of allyl ketones with nitrile oxides: direct access to 3,5-disubstituted isoxazolines

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Publication details

The article was received on 15 Sep 2016, accepted on 05 Oct 2016 and first published on 05 Oct 2016


Article type: Communication
DOI: 10.1039/C6OB02025A
Citation: Org. Biomol. Chem., 2016,14, 9985-9988
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    Enolate-mediated 1,3-dipolar cycloaddition reactions of allyl ketones with nitrile oxides: direct access to 3,5-disubstituted isoxazolines

    W. Li, X. Zhou, Z. Shi, Y. Liu, Z. Liu and H. Gao, Org. Biomol. Chem., 2016, 14, 9985
    DOI: 10.1039/C6OB02025A

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