Synthetic methods for 1,3-diamines

Abstract

1,3-Diamines not only are significant motifs in natural products, but also serve as building blocks in synthetic organic chemistry. However, unlike their 1,2-diamine counterparts, limited efforts have been devoted to the development of an effective synthetic approach to 1,3-diamines. In this review, the synthetic methods for the preparation of 1,3-diamines are summarized.