Issue 42, 2016
From the journal:

Organic & Biomolecular Chemistry

Silver-promoted decarboxylative amidation of α-keto acids with amines†

Xiao-Lan Xu,‡ac   Wen-Tao Xu,‡b   Ji-Wei Wu,a   Jian-Bo He*a  and  Hua-Jian Xu*b  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, P. R. China
E-mail: jbhe@hfut.edu.cn

b School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China
E-mail: hjxu@hfut.edu.cn

c School of Medical Science, Anhui Medical University, Hefei 230026, P. R. China

Abstract

A general and effective method for the synthesis of amides through decarboxylative amidation of α-keto acids with amines has been developed. The reaction proceeded smoothly to afford the corresponding amide products in good yield under air and shows excellent functional group tolerance. In addition, the protocol can be further applied in the synthesis of heterocyclic compounds like benzimidazoles.

Graphical abstract: Silver-promoted decarboxylative amidation of α-keto acids with amines

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Article information

DOI
https://doi.org/10.1039/C6OB01963C
Article type
Communication
Submitted
06 Sep 2016
Accepted
30 Sep 2016
First published
30 Sep 2016

Org. Biomol. Chem., 2016,14, 9970-9973

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Silver-promoted decarboxylative amidation of α-keto acids with amines

X. Xu, W. Xu, J. Wu, J. He and H. Xu, Org. Biomol. Chem., 2016, 14, 9970 DOI: 10.1039/C6OB01963C

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