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Issue 42, 2016
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Silver-promoted decarboxylative amidation of α-keto acids with amines

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Abstract

A general and effective method for the synthesis of amides through decarboxylative amidation of α-keto acids with amines has been developed. The reaction proceeded smoothly to afford the corresponding amide products in good yield under air and shows excellent functional group tolerance. In addition, the protocol can be further applied in the synthesis of heterocyclic compounds like benzimidazoles.

Graphical abstract: Silver-promoted decarboxylative amidation of α-keto acids with amines

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The article was received on 06 Sep 2016, accepted on 30 Sep 2016 and first published on 30 Sep 2016


Article type: Communication
DOI: 10.1039/C6OB01963C
Citation: Org. Biomol. Chem., 2016,14, 9970-9973
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    Silver-promoted decarboxylative amidation of α-keto acids with amines

    X. Xu, W. Xu, J. Wu, J. He and H. Xu, Org. Biomol. Chem., 2016, 14, 9970
    DOI: 10.1039/C6OB01963C

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