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Issue 43, 2016
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A Rh(II)-catalyzed three-component reaction of 3-diazooxindoles with N,N-disubstituted anilines and glyoxylates for the synthesis of 3-aryl-3-substituted oxindoles

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Abstract

A simple and effective method for the synthesis of 3-aryl-3-substituted oxindole derivatives via a [Rh]-catalyzed three-component reaction of 3-diazooxindoles with N,N-disubstituted anilines and glyoxylates is developed. This transformation is proposed to proceed through an intermolecular aldol-type trapping of zwitterionic intermediates.

Graphical abstract: A Rh(ii)-catalyzed three-component reaction of 3-diazooxindoles with N,N-disubstituted anilines and glyoxylates for the synthesis of 3-aryl-3-substituted oxindoles

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Publication details

The article was received on 30 Aug 2016, accepted on 03 Oct 2016 and first published on 04 Oct 2016


Article type: Communication
DOI: 10.1039/C6OB01907B
Citation: Org. Biomol. Chem., 2016,14, 10157-10160
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    A Rh(II)-catalyzed three-component reaction of 3-diazooxindoles with N,N-disubstituted anilines and glyoxylates for the synthesis of 3-aryl-3-substituted oxindoles

    S. Jia, L. Song, Y. Lei, A. Gopi Krishna Reddy, D. Xing and W. Hu, Org. Biomol. Chem., 2016, 14, 10157
    DOI: 10.1039/C6OB01907B

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