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Issue 42, 2016
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Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids

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Abstract

A copper mediated radical oxidative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids is developed. This study offers a new and expedient strategy for the synthesis of useful indolizines in moderate to good yields and exhibits a broad substrate scope and good functional group tolerance.

Graphical abstract: Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids

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Publication details

The article was received on 29 Aug 2016, accepted on 30 Sep 2016 and first published on 30 Sep 2016


Article type: Communication
DOI: 10.1039/C6OB01902A
Citation: Org. Biomol. Chem., 2016,14, 9966-9969
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    Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids

    J. Gu and C. Cai, Org. Biomol. Chem., 2016, 14, 9966
    DOI: 10.1039/C6OB01902A

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