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Issue 42, 2016
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Computation-guided improved one-pot synthesis of macrocyclic cation-binding aromatic pyridone pentamers

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Abstract

By using polar DMF to relax the H-bonded rigid backbone and to lower the energetic penalty associated with the sterically-crowded environment, the yields for BOP-mediated one-pot synthesis of pentameric macrocycles can be improved from 10–25% as obtained in CH2Cl2 to 13–47% when 15% DMF in CH2Cl2 was used as the reaction medium.

Graphical abstract: Computation-guided improved one-pot synthesis of macrocyclic cation-binding aromatic pyridone pentamers

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Publication details

The article was received on 23 Aug 2016, accepted on 08 Sep 2016 and first published on 08 Sep 2016


Article type: Communication
DOI: 10.1039/C6OB01841F
Citation: Org. Biomol. Chem., 2016,14, 9961-9965
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    Computation-guided improved one-pot synthesis of macrocyclic cation-binding aromatic pyridone pentamers

    V. Z. Zeng, H. Su and T. Li, Org. Biomol. Chem., 2016, 14, 9961
    DOI: 10.1039/C6OB01841F

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