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Issue 43, 2016
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Evolution of specific 3′-5′-linkages in RNA in pre-biotic soup: a new hypothesis

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Abstract

This article reviews the different possibilities towards progression of the formation of DNA/RNA in the chemical world, before life, in enzyme-free conditions. The advent of deoxyribo- and ribopentose-sugars, nucleosides, nucleotides and oligonucleotides in the prebiotic soup is briefly discussed. Further, the formation of early single stranded oligomers, base-pairing possibilities and information transfer based on the stability parameters of the derived duplexes is reviewed. Each theory has its own merits and demerits which we have elaborated upon. Lastly, using clues from this literature, a possible explanation for the specific 3′-5′-linkages in RNA is proposed.

Graphical abstract: Evolution of specific 3′-5′-linkages in RNA in pre-biotic soup: a new hypothesis

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Publication details

The article was received on 17 Aug 2016, accepted on 31 Aug 2016 and first published on 01 Sep 2016


Article type: Review Article
DOI: 10.1039/C6OB01796G
Citation: Org. Biomol. Chem., 2016,14, 10123-10133
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    Evolution of specific 3′-5′-linkages in RNA in pre-biotic soup: a new hypothesis

    V. A. Kumar, Org. Biomol. Chem., 2016, 14, 10123
    DOI: 10.1039/C6OB01796G

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