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Issue 42, 2016
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Bioactive norditerpenoids and neolignans from the roots of salvia miltiorrhiza

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Abstract

Two new norditerpenoids, miltiolactones A and B (1a, 1b); seven new neolignans, miltiolignanolides A–G (2a, 2b and 3a, 3b and 4a, 4b, and 5) were obtained from the root extract of Salvia miltiorrhiza. Using HPLC separation with a chiral column, compounds 1–4 were found to exist as four pairs of enantiomers. Compounds 2–5 are novel neolignans with a dibenzocycloheptatriene ring system, which form an unprecedented 6/7/6 carbon skeleton. The structures were established via extensive spectroscopic analysis, and experimental and calculated electronic circular dichroism (ECD) spectra, and compound 1 was also elucidated by X-ray diffraction experiments. Compounds 2a and 2b significantly increased the viability of H9c2 cells from H2O2-induced cell death, and 3a showed significant antioxidant activity in an ABTS assay. In addition, compounds 2a, 2b and 3a, 3b display moderate inhibitory effects on nitric oxide (NO) production in LPS-induced microglial cells.

Graphical abstract: Bioactive norditerpenoids and neolignans from the roots of salvia miltiorrhiza

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Publication details

The article was received on 16 Aug 2016, accepted on 20 Sep 2016, published on 20 Sep 2016 and first published online on 20 Sep 2016


Article type: Paper
DOI: 10.1039/C6OB01784C
Citation: Org. Biomol. Chem., 2016,14, 10050-10057
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    Bioactive norditerpenoids and neolignans from the roots of salvia miltiorrhiza

    L. Li, X. Liang, X. Sun, X. Qi, J. Wang, Q. Zhao and S. Song, Org. Biomol. Chem., 2016, 14, 10050
    DOI: 10.1039/C6OB01784C

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