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Issue 45, 2016
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Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach

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Abstract

A biomass-derived platform chemical was utilized to access a demanded pharmaceutical substance with anti-HIV activity (HIV, human immunodeficiency virus) and a variety of structural analogues. Step economy in the synthesis of the drug core (single stage from cellulose) is studied including flexible variability of four structural units. The first synthesis and X-ray structure of the inhibitor of HIV-1 capsid protein assembly (CAP-1) is described.

Graphical abstract: Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach

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Publication details

The article was received on 10 Aug 2016, accepted on 16 Sep 2016 and first published on 30 Sep 2016


Article type: Paper
DOI: 10.1039/C6OB01731B
Citation: Org. Biomol. Chem., 2016,14, 10593-10598
  • Open access: Creative Commons BY-NC license
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    Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach

    L. V. Romashov and V. P. Ananikov, Org. Biomol. Chem., 2016, 14, 10593
    DOI: 10.1039/C6OB01731B

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