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Issue 45, 2016
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Colorimetric and fluorescence probe for the detection of nano-molar lysine in aqueous medium

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Abstract

A single crystal X-ray structurally characterized BODIPY based probe, THBPY, derived from 4-hydroxy-5-isopropyl-2 methyl-isophthalaldehyde, detects nano-molar lysine in aqueous medium. In the presence of lysine, THBPY visibly changes its color and fluorescence profile due to the formation of a stable imine bond. A distinctive color change allows for facile discrimination over other amino acids in a wide range of concentrations of lysine. The detection limit for lysine is 0.001 μM by a fluorescence method and 0.01 μM by a colorimetric method. The probe shows good reversibility for multiple uses and cleanly discriminates between lysine and other amino acids. Density functional theoretical studies closely resemble experimental results.

Graphical abstract: Colorimetric and fluorescence probe for the detection of nano-molar lysine in aqueous medium

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Publication details

The article was received on 07 Aug 2016, accepted on 19 Oct 2016 and first published on 19 Oct 2016


Article type: Paper
DOI: 10.1039/C6OB01704E
Citation: Org. Biomol. Chem., 2016,14, 10688-10694
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    Colorimetric and fluorescence probe for the detection of nano-molar lysine in aqueous medium

    S. Adhikari, A. Ghosh, S. Mandal, S. Guria, P. P. Banerjee, A. Chatterjee and D. Das, Org. Biomol. Chem., 2016, 14, 10688
    DOI: 10.1039/C6OB01704E

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