Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 46, 2016
Previous Article Next Article

Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray

Author affiliations

Abstract

Sialic acids (Sias) are important terminal sugars on cell surfaces involved in a wide range of protein–carbohydrate interactions. Hence, agents modulating sias-mediated protein interactions are promising inhibitors or vaccine candidates. Here, we report the synthesis of Neu5Acα(2–6)Gal structural analogs and their binding to a series of siglecs. The results showed distinct binding patterns with conserved siglecs (hCD22 and mCD22) compared to rapid evolving siglecs (Siglecs -3 & -10).

Graphical abstract: Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 05 Aug 2016, accepted on 14 Sep 2016 and first published on 14 Sep 2016


Article type: Communication
DOI: 10.1039/C6OB01688J
Citation: Org. Biomol. Chem., 2016,14, 10812-10815
  •   Request permissions

    Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray

    R. Yadav, S. Leviatan Ben-Arye, B. Subramani, V. Padler-Karavani and R. Kikkeri, Org. Biomol. Chem., 2016, 14, 10812
    DOI: 10.1039/C6OB01688J

Search articles by author