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Issue 46, 2016
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Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray

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Abstract

Sialic acids (Sias) are important terminal sugars on cell surfaces involved in a wide range of protein–carbohydrate interactions. Hence, agents modulating sias-mediated protein interactions are promising inhibitors or vaccine candidates. Here, we report the synthesis of Neu5Acα(2–6)Gal structural analogs and their binding to a series of siglecs. The results showed distinct binding patterns with conserved siglecs (hCD22 and mCD22) compared to rapid evolving siglecs (Siglecs -3 & -10).

Graphical abstract: Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray

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Publication details

The article was received on 05 Aug 2016, accepted on 14 Sep 2016 and first published on 14 Sep 2016


Article type: Communication
DOI: 10.1039/C6OB01688J
Citation: Org. Biomol. Chem., 2016,14, 10812-10815
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    Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray

    R. Yadav, S. Leviatan Ben-Arye, B. Subramani, V. Padler-Karavani and R. Kikkeri, Org. Biomol. Chem., 2016, 14, 10812
    DOI: 10.1039/C6OB01688J

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