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Issue 42, 2016
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Highly enantioselective asymmetric Henry reaction catalyzed by novel chiral phase transfer catalysts derived from cinchona alkaloids

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Abstract

A new type of di-site chiral phase transfer catalyst has been designed and synthesized from cinchona alkaloids as a chiral precursor. The prepared catalysts are applied in the asymmetric Henry reaction to a wide range of aldehydes using mild concentrations of a base and solvent and under room-temperature conditions. Under the optimized reaction conditions, the highest chemical yields up to 99% along with an excellent enantiomeric excess (ee) up to 99% were obtained using the prepared cinchona alkaloid based chiral phase transfer catalysts.

Graphical abstract: Highly enantioselective asymmetric Henry reaction catalyzed by novel chiral phase transfer catalysts derived from cinchona alkaloids

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Publication details

The article was received on 05 Aug 2016, accepted on 01 Oct 2016 and first published on 04 Oct 2016


Article type: Paper
DOI: 10.1039/C6OB01687A
Citation: Org. Biomol. Chem., 2016,14, 10101-10109
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    Highly enantioselective asymmetric Henry reaction catalyzed by novel chiral phase transfer catalysts derived from cinchona alkaloids

    P. K. Vijaya, S. Murugesan and A. Siva, Org. Biomol. Chem., 2016, 14, 10101
    DOI: 10.1039/C6OB01687A

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