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Issue 46, 2016
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Supramolecular metalloglycodendrimers selectively modulate lectin binding and delivery of Ru(II) complexes into mammalian cells

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Abstract

A host–guest interaction between Ru(II)-complexes and sugar-capped β-cyclodextrin was employed to synthesize metalloglycodendrimers. These glycodendrimers demonstrated selective carbohydrate–protein interactions and controlled the delivery of the Ru(II) complexes into cancer cells, which may facilitate cell-specific apoptosis. Lectin binding assay revealed micromolar range IC50 values with different plant lectins. Cell viability assay and confocal imaging studies of Ru(II) complexes exhibited cytotoxic activities in cancer cells compared to normal cells with IC50 values close to other literature Ru(II) complexes. The cell death inducer was found to accumulate favorably to the endoplasmic reticulum (ER) and induced ER stress in cells. The upregulation of CHOP, caspase-3 and caspase-12 disturbed the ER morphology initiating the apoptosis pathway.

Graphical abstract: Supramolecular metalloglycodendrimers selectively modulate lectin binding and delivery of Ru(ii) complexes into mammalian cells

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Publication details

The article was received on 20 Jul 2016, accepted on 17 Sep 2016 and first published on 20 Sep 2016


Article type: Paper
DOI: 10.1039/C6OB01546H
Citation: Org. Biomol. Chem., 2016,14, 10816-10821
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    Supramolecular metalloglycodendrimers selectively modulate lectin binding and delivery of Ru(II) complexes into mammalian cells

    H. Bavireddi, R. Vasudeva Murthy, M. Gade, S. Sangabathuni and R. Kikkeri, Org. Biomol. Chem., 2016, 14, 10816
    DOI: 10.1039/C6OB01546H

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