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Issue 33, 2016
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Synthetic receptor molecules for selective fluorescence detection of 8-oxo-dGTP in aqueous media

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Abstract

A series of 9-hydroxy-1,3-diazaphenoxazine-2-one derivatives were synthesized as fluorescent receptor molecules for 8-oxo-dGTP, which attach the cyclen-zinc complex at the 3-N position as the binding site for the triphosphate and the (2-aryloxycarbonylamino)ethyl group at the 9-O position as the hydrogen bonding site for 8-oxoguanine. Among these molecules, the receptor molecule 5a-Zn constructed of the ethyl linker at 3-N and the (2-benzyloxycarbonyl amino)ethyl group at 9-O displayed the best recognition ability for 8-oxoguanosine triphosphate (8-oxo-dGTP) in aqueous media. The receptor 5a-Zn was also shown to selectively detect 8-oxo-dGTP in a cell lysate solution.

Graphical abstract: Synthetic receptor molecules for selective fluorescence detection of 8-oxo-dGTP in aqueous media

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Publication details

The article was received on 13 Jul 2016, accepted on 29 Jul 2016 and first published on 29 Jul 2016


Article type: Paper
DOI: 10.1039/C6OB01485B
Citation: Org. Biomol. Chem., 2016,14, 7949-7955
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    Synthetic receptor molecules for selective fluorescence detection of 8-oxo-dGTP in aqueous media

    Y. Fuchi, T. Fukuda and S. Sasaki, Org. Biomol. Chem., 2016, 14, 7949
    DOI: 10.1039/C6OB01485B

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