A facile approach for the synthesis of C13–C24 fragments of maltepolides A, C and D

Abstract

A linear, chiron approach for the synthesis of C13–C24 fragments of cytostatic maltepolides A, C and D consisting of a tetrahydrofuran subunit and a chiral alkenyl/alkyl substituent is achieved from (+)-diethyl L-tartrate. The other chiral stereocenters were generated by employing key reactions such as Crimmins aldol, alkynylation and CeCl₃·7H₂O mediated Luche reduction reactions.