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Issue 29, 2016
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A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

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Abstract

A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.

Graphical abstract: A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

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Publication details

The article was received on 26 May 2016, accepted on 24 Jun 2016 and first published on 24 Jun 2016


Article type: Communication
DOI: 10.1039/C6OB01148A
Citation: Org. Biomol. Chem., 2016,14, 6947-6950
  • Open access: Creative Commons BY-NC license
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    A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

    P. Wu, M. Å. Petersen, A. E. Cohrt, R. Petersen, R. Morgentin, H. Lemoine, C. Roche, A. Willaume, M. H. Clausen and T. E. Nielsen, Org. Biomol. Chem., 2016, 14, 6947
    DOI: 10.1039/C6OB01148A

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