Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 27, 2016
Previous Article Next Article

Organocatalytic azomethine imine-olefin click reaction: high-yielding stereoselective synthesis of spiroindane-1,3-dione-pyrazolidinones

Author affiliations

Abstract

In search of developing new useful “click reactions”, herein we report the organocatalytic azomethine imine-olefin [3 + 2]-cycloaddition as a new click reaction for the synthesis of drug-like spiroindane-1,3-dione-pyrazolidinones from indane-1,3-diones, aldehydes and N,N-cyclic azomethine imines through amino acid-catalysis. The scope of this new click reaction is demonstrated using many examples with high reactivity, selectivity and yields.

Graphical abstract: Organocatalytic azomethine imine-olefin click reaction: high-yielding stereoselective synthesis of spiroindane-1,3-dione-pyrazolidinones

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 09 May 2016, accepted on 03 Jun 2016 and first published on 06 Jun 2016


Article type: Paper
DOI: 10.1039/C6OB01009A
Citation: Org. Biomol. Chem., 2016,14, 6517-6522
  •   Request permissions

    Organocatalytic azomethine imine-olefin click reaction: high-yielding stereoselective synthesis of spiroindane-1,3-dione-pyrazolidinones

    D. B. Ramachary, T. Prabhakar Reddy and A. Suresh Kumar, Org. Biomol. Chem., 2016, 14, 6517
    DOI: 10.1039/C6OB01009A

Search articles by author