Issue 29, 2016

One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

Abstract

A one-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins has been realized for the preparation of chiral 3-aryl-3-aryloxy alcohols with excellent yields and good enantioselectivities. This methodology can be employed in new synthetic routes for the synthesis of fluoxetine, atomoxetine, and related analogues.

Graphical abstract: One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

Supplementary files

Article information

Article type
Paper
Submitted
22 Apr 2016
Accepted
24 Jun 2016
First published
28 Jun 2016

Org. Biomol. Chem., 2016,14, 7099-7102

One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

Y. Liu, J. Chen, Z. Zhang, J. Qin, M. Zhao and W. Zhang, Org. Biomol. Chem., 2016, 14, 7099 DOI: 10.1039/C6OB00871B

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