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Issue 29, 2016
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One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

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Abstract

A one-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins has been realized for the preparation of chiral 3-aryl-3-aryloxy alcohols with excellent yields and good enantioselectivities. This methodology can be employed in new synthetic routes for the synthesis of fluoxetine, atomoxetine, and related analogues.

Graphical abstract: One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

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Publication details

The article was received on 22 Apr 2016, accepted on 24 Jun 2016 and first published on 28 Jun 2016


Article type: Paper
DOI: 10.1039/C6OB00871B
Citation: Org. Biomol. Chem., 2016,14, 7099-7102
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    One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins

    Y. Liu, J. Chen, Z. Zhang, J. Qin, M. Zhao and W. Zhang, Org. Biomol. Chem., 2016, 14, 7099
    DOI: 10.1039/C6OB00871B

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