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Issue 22, 2016
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Different stabilities of liposomes containing saturated and unsaturated lipids toward the addition of cyclodextrins

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Abstract

Liposomes composed of unsaturated lipids were more stable than those containing saturated lipids toward DMe-β-CDx, DMe-α-CDx and DMe-β-CDx. The Hill coefficient values (n) indicated that the saturated lipid·DMe-CDx complexes had stoichiometric ratios in the range of 1 : 3–1 : 4, while the unsaturated lipid·DMe-CDx complexes had ratios in the range of 1 : 1.5–1 : 3. That is, a cis alkene group in the unsaturated lipids prevented complexation with a second DMe-CDx in the direction toward each acyl chain. Furthermore, the liposomes composed of the unsaturated lipids were much slower to form precipitates upon the addition of α-CDx than those of the saturated lipids. To the best of our knowledge, this is the first example showing that CDxs interact with unsaturated lipids.

Graphical abstract: Different stabilities of liposomes containing saturated and unsaturated lipids toward the addition of cyclodextrins

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Publication details

The article was received on 11 Mar 2016, accepted on 04 May 2016 and first published on 04 May 2016


Article type: Paper
DOI: 10.1039/C6OB00535G
Citation: Org. Biomol. Chem., 2016,14, 5065-5072
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    Different stabilities of liposomes containing saturated and unsaturated lipids toward the addition of cyclodextrins

    A. Ikeda, R. Funada and K. Sugikawa, Org. Biomol. Chem., 2016, 14, 5065
    DOI: 10.1039/C6OB00535G

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