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Issue 24, 2016
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Ruthenium photoredox-triggered phospholipid membrane formation

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Abstract

As more methodologies for generating and manipulating biomimetic cellular systems are developed, opportunities arise for combining different methods to create more complex synthetic biological constructs. This necessitates an increasing need for tools to selectively trigger individual methodologies. Here we demonstrate ruthenium tris-bipyridine mediated photoredox triggering of the copper catalyzed alkyne azide cycloaddition reaction (CuAAC), resulting in the synthesis of biomimetic phospholipids in situ, and subsequent membrane assembly. The use of a ruthenium–copper electron transport chain to trigger phospholipid assembly opens up future opportunities for spatiotemporal synthesis of membranes.

Graphical abstract: Ruthenium photoredox-triggered phospholipid membrane formation

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 03 Feb 2016, accepted on 22 Feb 2016 and first published on 22 Feb 2016


Article type: Communication
DOI: 10.1039/C6OB00290K
Citation: Org. Biomol. Chem., 2016,14, 5555-5558
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    Ruthenium photoredox-triggered phospholipid membrane formation

    M. D. Hardy, D. Konetski, C. N. Bowman and N. K. Devaraj, Org. Biomol. Chem., 2016, 14, 5555
    DOI: 10.1039/C6OB00290K

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