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Issue 24, 2016
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In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice

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Abstract

Advanced glycation end products (AGEs) are associated with various diseases, especially during aging and the development of diabetes and uremia. To better understand these biological processes, investigation of the in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Following the preparation of Cy7.5-labeled AGE-albumin and intravenous injection in BALB/cA-nu/nu mice, noninvasive fluorescence kinetics analysis was performed. In vivo imaging and fluorescence microscopy analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in the liver, i.e., Kupffer and other sinusoidal cells, but were unable to be properly cleared from the body. Overall, these results highlight an important link between AGEs and various disorders associated with them, which may serve as a platform for future research to better understand the processes and mechanisms of these disorders.

Graphical abstract: In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 14 Jan 2016, accepted on 25 Feb 2016 and first published on 25 Feb 2016


Article type: Paper
DOI: 10.1039/C6OB00098C
Citation: Org. Biomol. Chem., 2016,14, 5755-5760
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    In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice

    A. Tsutsui, A. Ogura, T. Tahara, S. Nozaki, S. Urano, M. Hara, S. Kojima, A. Kurbangalieva, H. Onoe, Y. Watanabe, N. Taniguchi and K. Tanaka, Org. Biomol. Chem., 2016, 14, 5755
    DOI: 10.1039/C6OB00098C

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